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Celecoxib is used to treat arthritis, pain, menstrual cramps, and colonic polyps. Before taking Celecoxib, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain. Individuals who have developed allergic reactions from aspirin or other NSAIDs may experience an allergic reaction to Celecoxib and should not take Celecoxib. Celebrex works by blocking the action of a substance in the body called cyclo-oxygenase.