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Metformin may be used with lifestyle changes such as diet and exercise program to control high blood sugar in people with type 2 diabetes the pancreas does not produce sufficient insulin and the cells of the body are resistant to the low levels of insulin circulating in the blood. Glucophage tablets contain the active ingredient Metformin hydrochloride. Metformin is used as a first line treatment of type 2 diabetes blood sugar levels can rise too high. Use this medication regularly in order to get the most benefit from it. Diabetes in people who are at high risk for becoming diabetic. Glucophage should be taken with meals. Metformin works by helping to restore your body's proper response to the insulin you naturally produce, and by decreasing the amount of sugar in your blood. Most obese patients are insulin resistant, and increasingly the type-2 diabetes medication Metformin is being prescribed to increase glucose sensitivity and promote weight loss process. Overall, Metformin reduces blood sugar levels.